ChouCho initially formed the band Lotus Lotus in 2007 when still in high school and performed covers of songs from anime. Starting in June 2008, ChouCho began submitting videos of her singing on the Nico Nico Douga video sharing website. On July 27, 2011, she made her major debut with her single "Kawaru Mirai" (カワルミライ?, lit. "Changing Future"), which is used as the opening theme to the 2011 anime Heaven's Memo Pad. Her second single "Authentic symphony" was released on October 26, 2011 and is used as the opening theme to the 2011 anime Mashiroiro Symphony. In August 2011, she released the album Lapis with the producer Junky. ChouCho's third single "Harmonia" (ハルモニア?) was released on November 23, 2011 and is used as the ending theme to the 2011 original video animation series The Legend of Heroes: Trails in the Sky. Her fourth single "Million of Bravery" was released on March 21, 2012 and is used as the theme song to the 2012 video game Kaku-San-Sei Million Arthur.
Her fifth single "Yasashisa no Riyū" (優しさの理由?, lit. "Reason of Kindness") was released on May 2, 2012 and is used as the opening theme to the 2012 anime Hyōka. ChouCho released her debut solo album Flyleaf on August 8, 2012, containing all previously released singles. Her sixth single "DreamRiser" was released on October 24, 2012 and is used as opening theme to the 2012 anime Girls und Panzer. Her seventh single "Sora to Kimi no Message" (空とキミのメッセージ?, lit. "Sky and Your Message") was released on May 22, 2013 and is used as the ending theme to the 2013 anime Gargantia on the Verdurous Planet. Her eighth single "Starlog" was released on July 31, 2013 and is used as the opening theme to the 2013 anime Fate/kaleid liner Prisma Illya. ChouCho's second studio album Secretgarden was released on December 25, 2013, containing her sixth through eighth singles. Her ninth single "Ano Sora ni Kaeru Mirai de" (あの空に還る未来で?) was released on February 26, 2014 and is used as the ending theme to the 2014 anime Buddy Complex. Her tenth single, "Natsu no Hi to Kimi no Koe" (夏の日と君の声?), was released on August 6, 2014 and is used as the opening theme to the 2014 anime Glasslip. Her 11th single, "Bless Your Name", was released on April 15, 2015, is used as the opening theme to the 2015 anime High School DxD BorN.