Matsuki Miyu was born on September 14, 1977 in Kure City, Hiroshima Prefecture, Japan. She is a voice actress affiliated with 81 Produce. Matsuki is a graduate of Hiroshima Jogakuin Junior & Senior High School and Keio University where she majored from the Faculty of Environment and Information Studies. Her blood type is A and her height is 151cm.
Her parents were officially against her becoming a voice actress but permitted her to move to Tokyo and visit the Keio University after she passed an entrance exam for it. After graduating from university she started pursuing her voice acting career and went at the same time to the Nichinare narration school and the Aksent voice acting school, where she later signed under after becoming professional.
She made her debut under her real name, Matsuki Mieko (松木美愛子) in 1988 on Nude Maker's PlayStation game Mikagura Shoujo Tanteidan. But changed shortly after to using a pseudonym instead as to protect her name.
In 2000 she passed an audition and became a member of newly established pop act Up Up under the Akatsuki Project label. In 2002 she got her first major role in an anime tv series, Shichinin no Nana. During the same year, in June, she quit Aksent and signed with talent agency 81 Produce. She became a regular on two radio shows, Sakurai Koubou and Cherry Bell in October 2002. The following years saw her involved with the Da Capo franchise a visual novel, adapted into an anime, where she played one of the main characters, Sagisawa Yoriko.